![]() ![]() ![]() Both cell viability and protein synthetic ability of LLC cells were reduced by treatment with morin, but C2C12 myotubes were not affected. Moreover, the tumor weight in mice fed the morin diet was lower than that in mice fed the normal diet. In contrast, intake of morin prevented the reduction of muscle wet weight and myofiber size. The wet weight and myofiber size of muscles in Lewis lung carcinoma (LLC) cell-bearing mice fed a normal diet were decreased, compared with those in control mice fed a normal diet. In this study, we examined the effect of morin, a flavonoid, on cachexia. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent muscle wasting in tumor-bearing mice. Cachexia, observed in most cancer patients, is a syndrome that includes wasting of bodily energy reserves and is characterized by muscle atrophy and fat loss. ![]()
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